Menu
Modern science
Soil Microbes Accelerate Global Warming

Bold New Approach to Wind 'Farm' Design May Provide Efficiency Gains

Soft Memory Device Opens Door to New Biocompatible Electronics

Most Elliptical Galaxies Are 'Like Spirals'

New Planets Feature Young Star and Twin Neptunes

Editing the Genome: Scientists Unveil New Tools for Rewriting the Code of Life

High Social Rank Comes at a Price, Wild Baboon Study Finds

Fossil Forensics Reveals How Wasps Populated Rotting Dinosaur Eggs

Monitoring Cellular Interactions at Nano-Scale in More Detail Than Ever Before

Non-Africans Are Part Neanderthal, Genetic Research Shows

Making Blood Sucking Deadly for Mosquitoes

Rising Oceans: Too Late to Turn the Tide?

Newly Developed Fluorescent Protein Makes Internal Organs Visible

NASA's Dawn Spacecraft Returns Close-Up Image of Giant Asteroid Vesta

Bacteria Use Batman-Like Grappling Hooks to 'Slingshot' On Surfaces, Study Shows

Mysterious Fossils Provide New Clues to Insect Evolution

Twisted Tale of Our Galaxy's Ring: Strange Kink in Milky Way

Engineering Excitable Cells for Studies of Bioelectricity and Cell Therapy

Ancient Footprints Show Human-Like Walking Began Nearly 4 Million Years Ago

Memories May Skew Visual Perception

Movement of Black Holes Powers Quasars, the Universe's Brightest Lights

First Artificial Neural Network Created out of DNA: Molecular Soup Exhibits Brainlike Behavior

Dolphins' 'Remarkable' Recovery from Injury Offers Important Insights for Human Healing

Cosmological Evolution of Dark Matter Is Similar to That of Visible Matter

Exoplanet Aurora: An Out-Of-This-World Sight

Monitoring Cellular Interactions at Nano-Scale in More Detail Than Ever Before
Using nanotechnology to engineer sensors onto the surface of cells, researchers at Brigham and Women's Hospital (BWH) have developed a platform technology for monitoring single-cell interactions in real-time. This innovation addresses needs in both science and medicine by providing the ability to further understand complex cell biology, track transplanted cells, and develop effective therapeutics. These findings are published in the July 17 issue of Nature Nanotechnology.

"We can now monitor how individual cells talk to one another in real-time with unprecedented spatial and temporal resolution," says Jeffrey Karp, senior study author, and co-director of the Center for Regenerative Therapeutics (ReGen Rx) at BWH. "This allows us to understand signaling between cells and interactions with drugs in great detail that should have broad implications for basic science and drug discovery",.

The cell-signaling sensors researchers currently use are limited to measuring the activity in the bulk environment that a group of cells are in. In this study, researchers used nanotechnology to anchor a sensor to the membrane of individual cells, allowing them to monitor soluble signals within the cellular nanoenvironment. Given that cells are directly labeled with sensors permits application to transplanted cells or tissues.

"Once this is refined as a tool, and used to study drug interactions with cells on a regular basis, there is potential that it may be used for personalized medicine in the future," said Weian Zhao, lead author of the study, also of the Center for Regenerative Therapeutics (ReGen Rx) at BWH. Karp adds, "We may one day be able to test a drug's influence on cell-cell interactions before deciding on the appropriate therapeutic for each person."

The researchers are also especially excited by preliminary data that demonstrates the potential to use this engineering approach to track and monitor the environment surrounding transplanted cells, in real time, which was never before possible. This would be useful for developing a deeper understanding of signaling events that define a site of inflammation for example or the stem cell niche, which may have implications for treatment of many diseases.

"This new study takes a significant step toward the goal to eavesdrop in real-time and at high spatial resolution on communications between cells in their native environment, with far-reaching implications for the development of new drugs and diagnostics" said Ulrich von Andrian, the Mallinckrodt Professor of Immunopathology at Harvard Medical School who was not involved in this study.

This work was funded by the National Institutes of Health and the American Heart Association.

Для печати

New Material Lets Electrons 'Dance' and Form New State

Cod Resurgence in Canadian Waters

Fundamental Matter-Antimatter Symmetry Confirmed

First True View of Global Erosion

NASA's WISE Finds Earth's First 'Trojan' Asteroid

Engineers Fly World's First 'Printed' Aircraft

Scientist Converts Human Skin Cells Into Functional Brain Cells

Rainforest Plant Developed 'Sonar Dish' to Attract Pollinating Bats

Sea Level Rise Less from Greenland, More from Antarctica, Than Expected During Last Interglacial

How Bats Stay On Target Despite the Clutter

Fall of the Neanderthals: Volume of Modern Humans Infiltrating Europe Cited as Critical Factor

Largest-Ever Map of Plant Protein Interactions

Some Plants Duplicate Their DNA to Overcome Adversity

serial to network

Menu
Diamonds Pinpoint Start of Colliding Continents

Researchers Identify Seventh and Eighth Bases of DNA

Fool's Gold Gives Scientists Priceless Insight Into Earth's Evolution

Astronomers Discover Largest and Most Distant Reservoir of Water Yet

Major Step Toward Creating Faster Electronics Using Graphene

New Photonic Crystals Have Both Electronic and Optical Properties

Epigenetic 'Memory' Key to Nature Versus Nurture

Climate Change to Increase Yellowstone Wildfires Dramatically

Retinal Cells Thoughts to Be the Same Are Not, Biologist Says

Minority Rules: Scientists Discover Tipping Point for the Spread of Ideas

Mitochondria Share an Ancestor With SAR11, a Globally Significant Marine Microbe

Drug Shown to Improve Sight for Patients With Inherited Blindness

Elliptical Galaxies Are Not Dead

Hubble Constant: A New Way to Measure the Expansion of the Universe

Enceladus Rains Water Onto Saturn

Engineers Develop One-Way Transmission System for Sound Waves

Researchers Graft Olfactory Receptors Onto Nanotubes

New Invisibility Cloak Hides Objects from Human View

Bionic Microrobot Mimics the 'Water Strider' and Walks On Water

How Memory Is Lost: Loss of Memory Due to Aging May Be Reversible

Reservoirs of Ancient Lava Shaped Earth

Wave Power Can Drive Sun's Intense Heat

Social Deficits Associated With Autism, Schizophrenia Induced in Mice With New Technology

Tundra Fires Could Accelerate Climate Warming

Chandra X-Ray Observatory Images Gas Flowing Toward Black Hole